This site is dedicated to patients with a subgroup of renal cell carcinoma and other cancers that involve chromosome translocations involving TFE3 or TFEB genes. Other names for these neoplasms in the literature include Xp11 translocation renal cell carcinoma, TFE3 rearranged renal cell carcinoma, Xp11 translocation PEComa, melanotic Xp11 translocation cancer, t(6;11) translocation renal cell carcinoma, and TFEB rearranged renal cell carcinoma, and MiT family translocation carcinoma. These neoplasms were originally described at Johns Hopkins by Dr. Pedram Argani, M.D., Professor of Pathology and Oncology, who maintains this site. The purpose of this site is to provide a resource to these patients and their families. Included in this site are educational materials, links to the latest research on these neoplasms, and opportunities to contribute to the understanding of these neoplasms. We hope this site is useful to these patients and their families.